Special warnings

In order to achieve optimum effectiveness, the veterinary medicinal product should only be used when there is no brood present or when the brood is at its lowest level. As oxalic acid does not penetrate the wax, mites in the sealed brood cells are not killed, so the presence of brood can significantly reduce the efficacy of the veterinary medicinal product. The brood stage and climatic conditions must be taken into account before applying the veterinary medicinal product. The effect of the veterinary medicinal product is exclusively through direct contact (through contact of adult bees with oxalic acid in the strip and through contact between the bees). Therefore, the veterinary medicinal product should be applied when the bees are still active, i.e. before the bees form a winter cluster, although the exact timing may vary depending on the climate zone. Despite proper treatment, severely damaged colonies may not survive due to earlier effects of Varroa infestation. Efficacy may vary between colonies depending on application conditions (temperature, re-infestation, etc.). No clinical data on efficacy and tolerability have been presented for conditions other than autumn in southern Europe. The veterinary medicinal product should be used as part of an integrated varroa management program with regular monitoring of mite decline. Where possible, the use of this veterinary medicinal product should be alternated with another approved varroacide with a different mechanism of action to reduce the risk of resistance development. The use of a ground net with a metal mesh of approximately 3 x 3 mm is recommended as part of a comprehensive varroa control program that includes the use of the veterinary medicinal product.

Special precautions for safe use on target species

All colonies in the same apiary should be treated at the same time to avoid reinfestation. The strips must not be reused. The colonies should be checked regularly during the treatment and for a certain period afterwards for the degree of Varroa mite infestation. The effect of the veterinary medicinal product in the presence of honey chambers has not been investigated. Therefore, the veterinary medicinal product should not be used in the hive when honey chambers are in place.

Special precautions for the user

The veterinary medicinal product may cause irritation to the skin, eyes and mucous membranes.
Take care to avoid contact of skin, eyes or mouth with the veterinary medicinal product.
When handling the veterinary medicinal product, the user should wear protective equipment consisting of the usual beekeeper's protective clothing and gloves.
In case of accidental skin contact, wash thoroughly with soap and water.
In case of accidental eye contact, flush eyes with plenty of clean, running water.
If skin/eye irritation persists, seek medical advice immediately and show the package leaflet or label.

Interaction with other medicinal products and other interactions

Do not use at the same time as other acaricides.

Overdosage

No adverse reactions were observed when 2 strips per hive containing 10 g oxalic acid dihydrate each were administered over a period of 6 weeks or 4 strips per hive (applied as two consecutive treatments of 3 weeks using 2 strips per hive/treatment) containing 10 g oxalic acid dihydrate each in two consecutive treatments of 3 weeks (2 strips per hive/treatment).

Side effects

None known.

Dosage for each species, type and duration of application

Use two strips per hive (i.e. 12.88 g oxalic acid dihydrate per hive) and hang one strip between two frames of honeycomb. Place the strips between the frames where the bees have the most freedom of movement. Hang the strips in such a way that the bees have free access to both sides and at the same time there is enough space for the bees. The strips have two folding lines so that the length of the strip can be adapted to the characteristics of each type of hive. The folding lines allow the strips to be used both in hives that require long strips (~30 cm) and in hives that require short strips (~25 cm).

Instructions for correct application

Strips must be removed after 6 weeks.
The strips must not be cut.
The veterinary medicine should be used when the amount of brood is low compared to the maximum levels. In addition, the veterinary medicine should be applied when the bees are still active, i.e. before the bees form a winter cluster, although the exact timing may vary depending on the climate zone. Therefore, the brood status and climatic conditions must be taken into account before applying the veterinary medicinal product.
Do not continue to use the veterinary medicinal product if you notice visible signs of deterioration.

Waiting periods

Honey: Zero days.
Do not use during the honey harvest. Do not remove honey from the brood chamber.
Do not harvest honey during the 6-week treatment period.

Special storage instructions

Keep medicine out of the reach of children.
No special storage conditions are required for this veterinary medicinal product.
Do not use this veterinary medicinal product after the expiry date stated on the label after "Exp.". The expiry date refers to the last day of the month.

Special precautions for disposal

EN: Unused veterinary medicinal products should preferably be disposed of at hazardous waste collection points. If disposed of together with household waste, it must be ensured that this waste cannot be misused. Veterinary medicinal products must not be disposed of with waste water or via the sewage system.
AT: Medicinal products should not be disposed of with waste water or household waste. Use take-back systems for the disposal of unused veterinary medicinal products or waste arising from them in accordance with local regulations and the national collection systems applicable to the veterinary medicinal product concerned.
AT/DE: These measures serve to protect the environment.
Ask your veterinarian or pharmacist how to dispose of medicines that are no longer needed.

Laboratorios Calier S.A.
C/ Barcelona 26
Poligono Industrial El Ramassa
Les Franqueses del Vallès
Barcelona
08520 Spain

pharmacovigilance@calier.es